Quantitation of non‐motor symptoms in Parkinson’s disease
Identifieur interne : 002831 ( Main/Corpus ); précédent : 002830; suivant : 002832Quantitation of non‐motor symptoms in Parkinson’s disease
Auteurs : K. Ray Chaudhuri ; P. Martinez-MartinSource :
- European Journal of Neurology [ 1351-5101 ] ; 2008-09.
English descriptors
Abstract
Background: Disabling non‐motor symptoms (NMS) associated with Parkinson’s disease (PD), such as dementia and loss of balance, do not respond well to levodopa therapy and can lead to eventual death in patients with the disease. In 2006, a multidisciplinary group of experts and patient representatives developed an NMS screening questionnaire (NMSQuest) and a unified Non‐Motor Symptoms Scale (NMSS) to address the need for simple identification and comprehensive assessment of NMS in patients with PD. Methods and Results: An international pilot study of 96 healthy controls and 123 patients with various stages of treated and untreated PD was conducted to demonstrate that the NMSQuest is a feasible, valid, and accepted tool. Conclusion: The majority of patients and caregivers felt that the questionnaire was clear and relevant to their daily lives. Data from 242 PD patients with no dementia were analysed in a pilot study on the clinimetric validation of NMSS. Similar to the NMSQuest study, the NMSS study revealed a significant correlation between progression of PD and increasing NMS burden. These studies suggest that the NMSQuest accurately detects the NMS, and that the NMSS closely correlates with quality of life for PD patients.
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DOI: 10.1111/j.1468-1331.2008.02212.x
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Ray Chaudhuri</name><affiliation><mods:affiliation>National Parkinson Foundation Centre of Excellence, King’s College Hospital, University Hospital Lewisham, Kings College and Institute of Psychiatry, London, UK</mods:affiliation></affiliation></author><author><name sortKey="Martinez Artin, P" sort="Martinez Artin, P" uniqKey="Martinez Artin P" first="P." last="Martinez-Martin">P. Martinez-Martin</name><affiliation><mods:affiliation>National Centre for Epidemiology, Carlos III Institute of Health, Madrid, Spain</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Neurology</title><idno type="ISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2008-09">2008-09</date><biblScope unit="volume">15</biblScope><biblScope unit="supplement">s2</biblScope><biblScope unit="page" from="2">2</biblScope><biblScope unit="page" to="8">8</biblScope></imprint><idno type="ISSN">1351-5101</idno></series><idno type="istex">054E5BB0FA589F15ADD55A43CAFEA3F457C12453</idno><idno type="DOI">10.1111/j.1468-1331.2008.02212.x</idno><idno type="ArticleID">ENE2212</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1351-5101</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson’s disease</term><term>clinimetrics</term><term>non‐motor symptoms</term><term>questionnaire</term><term>scale</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Disabling non‐motor symptoms (NMS) associated with Parkinson’s disease (PD), such as dementia and loss of balance, do not respond well to levodopa therapy and can lead to eventual death in patients with the disease. In 2006, a multidisciplinary group of experts and patient representatives developed an NMS screening questionnaire (NMSQuest) and a unified Non‐Motor Symptoms Scale (NMSS) to address the need for simple identification and comprehensive assessment of NMS in patients with PD. Methods and Results: An international pilot study of 96 healthy controls and 123 patients with various stages of treated and untreated PD was conducted to demonstrate that the NMSQuest is a feasible, valid, and accepted tool. Conclusion: The majority of patients and caregivers felt that the questionnaire was clear and relevant to their daily lives. Data from 242 PD patients with no dementia were analysed in a pilot study on the clinimetric validation of NMSS. Similar to the NMSQuest study, the NMSS study revealed a significant correlation between progression of PD and increasing NMS burden. These studies suggest that the NMSQuest accurately detects the NMS, and that the NMSS closely correlates with quality of life for PD patients.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>K. Ray Chaudhuri</name><affiliations><json:string>National Parkinson Foundation Centre of Excellence, King’s College Hospital, University Hospital Lewisham, Kings College and Institute of Psychiatry, London, UK</json:string></affiliations></json:item><json:item><name>P. 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In 2006, a multidisciplinary group of experts and patient representatives developed an NMS screening questionnaire (NMSQuest) and a unified Non‐Motor Symptoms Scale (NMSS) to address the need for simple identification and comprehensive assessment of NMS in patients with PD. Methods and Results: An international pilot study of 96 healthy controls and 123 patients with various stages of treated and untreated PD was conducted to demonstrate that the NMSQuest is a feasible, valid, and accepted tool. Conclusion: The majority of patients and caregivers felt that the questionnaire was clear and relevant to their daily lives. Data from 242 PD patients with no dementia were analysed in a pilot study on the clinimetric validation of NMSS. Similar to the NMSQuest study, the NMSS study revealed a significant correlation between progression of PD and increasing NMS burden. 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Ray</forename><surname>Chaudhuri</surname></persName><affiliation>National Parkinson Foundation Centre of Excellence, King’s College Hospital, University Hospital Lewisham, Kings College and Institute of Psychiatry, London, UK</affiliation></author><author><persName><forename type="first">P.</forename><surname>Martinez‐Martin</surname></persName><affiliation>National Centre for Epidemiology, Carlos III Institute of Health, Madrid, Spain</affiliation></author></analytic><monogr><title level="j">European Journal of Neurology</title><idno type="pISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><idno type="DOI">10.1111/(ISSN)1468-1331</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2008-09"></date><biblScope unit="volume">15</biblScope><biblScope unit="supplement">s2</biblScope><biblScope unit="page" from="2">2</biblScope><biblScope unit="page" to="8">8</biblScope></imprint></monogr><idno type="istex">054E5BB0FA589F15ADD55A43CAFEA3F457C12453</idno><idno type="DOI">10.1111/j.1468-1331.2008.02212.x</idno><idno type="ArticleID">ENE2212</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2008</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Background: Disabling non‐motor symptoms (NMS) associated with Parkinson’s disease (PD), such as dementia and loss of balance, do not respond well to levodopa therapy and can lead to eventual death in patients with the disease. In 2006, a multidisciplinary group of experts and patient representatives developed an NMS screening questionnaire (NMSQuest) and a unified Non‐Motor Symptoms Scale (NMSS) to address the need for simple identification and comprehensive assessment of NMS in patients with PD. Methods and Results: An international pilot study of 96 healthy controls and 123 patients with various stages of treated and untreated PD was conducted to demonstrate that the NMSQuest is a feasible, valid, and accepted tool. Conclusion: The majority of patients and caregivers felt that the questionnaire was clear and relevant to their daily lives. Data from 242 PD patients with no dementia were analysed in a pilot study on the clinimetric validation of NMSS. Similar to the NMSQuest study, the NMSS study revealed a significant correlation between progression of PD and increasing NMS burden. These studies suggest that the NMSQuest accurately detects the NMS, and that the NMSS closely correlates with quality of life for PD patients.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>clinimetrics</term></item><item><term>non‐motor symptoms</term></item><item><term>Parkinson’s disease</term></item><item><term>questionnaire</term></item><item><term>scale</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2008-09">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/054E5BB0FA589F15ADD55A43CAFEA3F457C12453/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1468-1331</doi><issn type="print">1351-5101</issn><issn type="electronic">1468-1331</issn><idGroup><id type="product" value="ENE"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="EUROPEAN JOURNAL OF NEUROLOGY">European Journal of Neurology</title></titleGroup></publicationMeta><publicationMeta level="part" position="09000"><doi origin="wiley">10.1111/ene.2008.15.issue-s2</doi><titleGroup><title type="specialIssueTitle">Dopamine Agonists in Parkinson’s Disease ‐ Focus on Non‐motor Symptoms</title></titleGroup><numberingGroup><numbering type="journalVolume" number="15">15</numbering><numbering type="supplement">s2</numbering></numberingGroup><coverDate startDate="2008-09">September 2008</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="2" status="forIssue"><doi origin="wiley">10.1111/j.1468-1331.2008.02212.x</doi><idGroup><id type="unit" value="ENE2212"></id></idGroup><countGroup><count type="pageTotal" number="7"></count></countGroup><titleGroup><title type="tocHeading1">Original Articles</title></titleGroup><copyright>© 2008 The Author(s). Journal compilation © 2008 EFNS</copyright><eventGroup><event type="firstOnline" date="2008-08-12"></event><event type="publishedOnlineFinalForm" date="2008-08-12"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.4 mode:FullText source:FullText result:FullText" date="2010-03-30"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-24"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-16"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="2">2</numbering><numbering type="pageLast" number="8">8</numbering></numberingGroup><correspondenceTo>K. Ray Chaudhuri, National Parkinson Foundation Centre of Excellence, King’s College Hospital, University Hospital Lewisham, Kings College and Institute of Psychiatry, London, UK (tel.: +44 207 346 8336; fax: +44 208 333 3093; e‐mail: <email>Ray.Chaudhuri@uhl.nhs.uk</email>).</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:ENE.ENE2212.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received 14 December 2007 Accepted 16 March 2008</unparsedEditorialHistory><countGroup><count type="figureTotal" number="3"></count><count type="tableTotal" number="4"></count></countGroup><titleGroup><title type="main">Quantitation of non‐motor symptoms in Parkinson’s disease</title><title type="shortAuthors">K. R. Chaudhuri</title><title type="short">Quantitation of non‐motor symptoms in PD</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>K. Ray</givenNames><familyName>Chaudhuri</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2"><personName><givenNames>P.</givenNames><familyName>Martinez‐Martin</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="GB"><unparsedAffiliation>National Parkinson Foundation Centre of Excellence, King’s College Hospital, University Hospital Lewisham, Kings College and Institute of Psychiatry, London, UK</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="ES"><unparsedAffiliation>National Centre for Epidemiology, Carlos III Institute of Health, Madrid, Spain</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">clinimetrics</keyword><keyword xml:id="k2">non‐motor symptoms</keyword><keyword xml:id="k3">Parkinson’s disease</keyword><keyword xml:id="k4">questionnaire</keyword><keyword xml:id="k5">scale</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b>Background: </b> Disabling non‐motor symptoms (NMS) associated with Parkinson’s disease (PD), such as dementia and loss of balance, do not respond well to levodopa therapy and can lead to eventual death in patients with the disease. In 2006, a multidisciplinary group of experts and patient representatives developed an NMS screening questionnaire (NMSQuest) and a unified Non‐Motor Symptoms Scale (NMSS) to address the need for simple identification and comprehensive assessment of NMS in patients with PD.</p><p><b>Methods and Results: </b> An international pilot study of 96 healthy controls and 123 patients with various stages of treated and untreated PD was conducted to demonstrate that the NMSQuest is a feasible, valid, and accepted tool.</p><p><b>Conclusion: </b> The majority of patients and caregivers felt that the questionnaire was clear and relevant to their daily lives. Data from 242 PD patients with no dementia were analysed in a pilot study on the clinimetric validation of NMSS. Similar to the NMSQuest study, the NMSS study revealed a significant correlation between progression of PD and increasing NMS burden. These studies suggest that the NMSQuest accurately detects the NMS, and that the NMSS closely correlates with quality of life for PD patients.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Quantitation of non‐motor symptoms in Parkinson’s disease</title></titleInfo><titleInfo type="abbreviated"><title>Quantitation of non‐motor symptoms in PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Quantitation of non‐motor symptoms in Parkinson’s disease</title></titleInfo><name type="personal"><namePart type="given">K. Ray</namePart><namePart type="family">Chaudhuri</namePart><affiliation>National Parkinson Foundation Centre of Excellence, King’s College Hospital, University Hospital Lewisham, Kings College and Institute of Psychiatry, London, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Martinez‐Martin</namePart><affiliation>National Centre for Epidemiology, Carlos III Institute of Health, Madrid, Spain</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2008-09</dateIssued><edition>Received 14 December 2007 Accepted 16 March 2008</edition><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">4</extent></physicalDescription><abstract lang="en">Background: Disabling non‐motor symptoms (NMS) associated with Parkinson’s disease (PD), such as dementia and loss of balance, do not respond well to levodopa therapy and can lead to eventual death in patients with the disease. In 2006, a multidisciplinary group of experts and patient representatives developed an NMS screening questionnaire (NMSQuest) and a unified Non‐Motor Symptoms Scale (NMSS) to address the need for simple identification and comprehensive assessment of NMS in patients with PD. Methods and Results: An international pilot study of 96 healthy controls and 123 patients with various stages of treated and untreated PD was conducted to demonstrate that the NMSQuest is a feasible, valid, and accepted tool. Conclusion: The majority of patients and caregivers felt that the questionnaire was clear and relevant to their daily lives. Data from 242 PD patients with no dementia were analysed in a pilot study on the clinimetric validation of NMSS. Similar to the NMSQuest study, the NMSS study revealed a significant correlation between progression of PD and increasing NMS burden. These studies suggest that the NMSQuest accurately detects the NMS, and that the NMSS closely correlates with quality of life for PD patients.</abstract><subject lang="en"><genre>Keywords</genre><topic>clinimetrics</topic><topic>non‐motor symptoms</topic><topic>Parkinson’s disease</topic><topic>questionnaire</topic><topic>scale</topic></subject><relatedItem type="host"><titleInfo><title>European Journal of Neurology</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">1351-5101</identifier><identifier type="eISSN">1468-1331</identifier><identifier type="DOI">10.1111/(ISSN)1468-1331</identifier><identifier type="PublisherID">ENE</identifier><part><date>2008</date><detail type="title"><title>Dopamine Agonists in Parkinson’s Disease ‐ Focus on Non‐motor Symptoms</title></detail><detail type="volume"><caption>vol.</caption><number>15</number></detail><detail type="supplement"><caption>Suppl. no.</caption><number>s2</number></detail><extent unit="pages"><start>2</start><end>8</end><total>7</total></extent></part></relatedItem><identifier type="istex">054E5BB0FA589F15ADD55A43CAFEA3F457C12453</identifier><identifier type="DOI">10.1111/j.1468-1331.2008.02212.x</identifier><identifier type="ArticleID">ENE2212</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2008 The Author(s). 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